MLI in Pathology
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Histopathology, the study of diseased tissue, is crucial for cancer diagnosis, drug development, and treatment. Despite over a century of use, the traditional histology process -- resection, fixation, embedding, sectioning, chemically staining, and microscopy — remains largely unchanged. Modern advancements include digitally scanning stained tissues, but the process remains destructive, requiring a new sample for each analysis. MLI digital pathology eliminates chemical stains, allows multiple analyses on a single scan, and can be performed on fresh, unstained tissue.
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Multi-Laser Imaging (MLI) is transforming digital pathology by providing rich data for advanced AI-assisted diagnostics. MLI offers a completely optical, non-contact approach to capture the full range of light-matter interactions while avoiding chemical stains and labeling. This allows AI to apply multiplexed virtual stains to a single sample, bypassing the need for multiple physical stains. Beyond traditional stains, MLI generates unique native contrasts of biomolecules through Total Absorption (TA) and Quantum Efficiency Ratio (QER) analysis. To learn more about MLI Technology, visit our Technology page. |
MLI Advanced Imaging Device (AID) for Life Sciences
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MLI Advanced Imaging Device (AID): Accelerate discoveries in life science research with MLI AID, uniquely capable of multiplexed virtual stains and native molecular contrasts. With just one scan, uncover all the answers you need. Samples: Unstained FFPE Slides, or Unstained thin fresh tissue (squash prep or vibratome) Contrasts: Virtual Stains: H&E, Masson’s Trichrome, T-Blue, PAS, + more Native Molecular Visualization: Total Absorption (TA) and Quantum Efficiency Ratio (QER) |
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Clinical Advisory Board
Prof. Dr. med. Danny Jonigk, FRCPath
University RWTH Aachen Chairman Institute of Pathology "PARS provide a unique opportunity for hands-on diagnostics, as well as for translational research in Life Sciences to analyze diseases like never before. In clinical pathology PARS paves the way for faster and more precise medicine, very likely improving diagnostic modalities and patients outcome." |
Ally-Khan Somani, MD, PhD, EMBA, FAAD, FACMS, FASDS, FEADV
Director of Dermatologic and Mohs Micro/Reconstructive Surgery at SkinMD Adjunct Clinical Assistant Professor of Dermatology and Otolaryngology-Head and Neck Surgery at the IU School of Medicine. "It will significantly simplify and streamline Mohs surgery. I expect it to let me treat more patients and treat them more effectively. I'm especially excited by the potential for PARS to identify and highlight the distinct molecular signatures of skin cancer, giving me information during the procedure that will enhance my ability to treat skin cancers and optimize patient care." |
David C. Adams, M.D., FACMS
Mohs Micrographic Surgery Specialist Coastal Skin Surgery & Dermatology “With results ready in 5 minutes vs the current 30 min I can be, maybe, 20% - 25% more productive overall and give the patient a better experience. I can literally step out of the patient room and be back in three or five minutes with the answer. They don’t need to wait and are still numb if I need to take another stage.” |
Related Publications
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2024/05 - IEEE
Automated Whole Slide Imaging for Label-Free Histology using Photon Absorption Remote Sensing Microscopy James Tweel, Benjamin Ecclestone, Marian Boktor, Deepak Dinakaran, John R. Mackey, Parsin Haji Reza Read / Download |
2024/01 - Scientific Reports
Multi-channel feature extraction for virtual histological staining of photon absorption remote sensing images. Marian Boktor, James Tweel, Benjamin Ecclestone, Jennifer Ye, Paul Fieguth, Parsin Haji Reza Read / Download |
2023/ 11 - MDPI Current Oncology
Photon Absorption Remote Sensing Imaging of Breast Needle Core Biopsies Is Diagnostically Equivalent to Gold Standard H&E Histologic Assessment. James Tweel, Benjamin Ecclestone, Hager Gaouda, Deepak Dinakaran, Michael P. Wallace, Gilbert Bigras, John R. Mackey, Parsin Haji Reza Read / Download |
Related News
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2023/11
IllumiSonics Inc., Announces Publication of Landmark Clinical Validation Study in Breast Cancer PARS® H&E images equivalent to traditional gold-standard H&E images with 98% diagnostic concordance for cancer versus benign. read more |
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2023/07
IllumiSonics label-free fresh tissue histology imaging to be presented at the 25th World Congress of Dermatology illumiSonics, a leader in label-free imaging, is pleased to announce that Dr. Ally-Khan Somani will be presenting on PARS fresh skin tissue imaging at the 25th World Congress of Dermatology in Singapore, July 3rd-8th, 2023. read more |