Multi-Laser Imaging (MLI®)
Multi-Laser Imaging (MLI®) is our patented label-free optical microscopy technique. By capturing all the interactions of light with matter, MLI® gives detailed molecular images without the need for tissue stains.
MLI® measures the dominant effects following the absorption of pulsed ultraviolet light. Using a co-focused detection laser, MLI® simultaneously measures non-radiative, radiative, and scattering interactions to reveal the unique total absorption signatures of the biomolecules within tissue.
MLI® Absorption Contrasts
MLI® Total Absorption Contrast
Our MLI® Total Absorption Contrast captures a complete picture of the optical absorption of UV light. This offers an unparalleled stain-free view of tissue structures while measuring the quantum yields of biomolecules.
MLI® Non-Radiative Contrast
Our MLI® Non-Radiative Contrast captures a detailed view of the energy deposited in the sample. Optimized for DNA absorption, this gives rich quantitative nuclear detail.
MLI® Radiative Contrast
Our MLI® Radiative Contrast captures the complete spectral signature of autofluorescent light emitted from the sample. By binning the emissions into distinct wavelengths we can provide hyperspectral information for each pixel.
MLI® Scattering Contrast
Our MLI® Scattering Contrast captures the attenuation and scattering of light passing through the sample. This provides detailed imaging of morphological structures and mapping of near-UV absorbers.
Interested in working with us?
Our MLI® Advanced Imaging Device is ready to digitize your existing tissue repositories converting them into rich multi-channel molecular imaging data.
We are eager to work with new partners towards ambitious goals in AI-assisted diagnostics, custom biomarker analysis, and predictive algorithms for disease progression risk.
