ILLUMISONICS IS A COMPANY BASED ON NEW PHYSICS (PARS®)
​TO ILLUMINATE DEEP DATA​

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​The Technology

PARS® is a Transformative Imaging Device
​for Life Science Research, Digital Pathology and Fresh Tissue Diagnostics

PARS® is the most advanced optical absorption imaging device to date. It captures optical absorption from radiative contrast (e.g., autofluorescence), non-radiative relaxation (e.g., temperature, pressure) and scattering channels (indirect optical absorption measurement) simultaneously without contact with the tissue.
* PARS stands for Photon Absorption Remote Sensing AKA PhotoAcoustic Remote Sensing

HOW PARS® WORKS

A picosecond scale pulsed excitation laser is focused into biological tissues to generate radiative (i.e., optical emissions), non-radiative (i.e., heat and pressure), and scattering effects in the sample.

Absorbed photons are captured and converted into different forms of emission from the sample (non-radiative and radiative), while scattered photons continue moving through and interacting with other portions of the sample.

Non-radiative effects are recorded using a secondary confocal detection beam, enabling the detection of temperature and pressure changes as close to the source as possible. These changes are registered as modulations in backscattering intensity, which are then directly correlated to the local non-radiative absorption contrast. 

The unperturbed backscatter (pre-excitation event) simultaneously captures the optical scattering contrast.

All captured contrasts can then be combined or visualized separately.

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Prof. Dr. med. Danny Jonigk, FRCPath 
University RWTH Aachen
Chairman Institute of Pathology

"PARS provide a unique opportunity for hands-on diagnostics, as well as for translational research in Life Sciences to analyze diseases like never before. In clinical pathology PARS paves the way for faster and more precise medicine, very likely improving diagnostic modalities and patients outcome." 

Ally-Khan Somani, MD, PhD, EMBA, FAAD, FACMS, FASDS, FEADV
Director of Dermatologic and Mohs Micro/Reconstructive Surgery at SkinMD Chicago
Adjunct Clinical Assistant Professor of Dermatology and Otolaryngology-Head and Neck Surgery at the IU School of Medicine.
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"It will significantly simplify and streamline Mohs surgery. I expect it to let me treat more patients and treat them more effectively. I'm especially excited by the potential for PARS to identify and highlight the distinct molecular signatures of skin cancer, giving me information during the procedure that will enhance my ability to treat skin cancers and optimize patient care."

David C. Adams, M.D., FACMS
Mohs Micrographic Surgery Specialist
Coastal Skin Surgery & Dermatology

“With results ready in 5 minutes vs the current 30 min  I can be, maybe, 20% - 25% more productive overall and give the patient a better experience. I can literally step out of the patient room and be back in three or five minutes with the answer. They don’t need to wait and are still numb if I need to take another stage.”

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PARS Multiplex Video of Normal Skin Tissue 

Dr. Ally-Khan Somani, MD, PhD, EMBA, a board-certified dermatologist and micrographic surgeon presents PARS multiplex imaging from a single unstained slide. 

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